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GLYR1 was shown to catalyze the conversion of glyoxylate to glycolate, and succinic semialdehyde to -hydroxybutyrate 29

Low levels of potentially toxic oxygen metabolites are physiologically generated in cells and tissues during oxidative phosphorylation.10 The resulting moderate levels of ROS play an integral role in the modulation of several physiological functions of the cell, including gene expression, signal transduction, and defense against invading pathogens

The detailed description of the protocol used as well as demographic and clinical characteristics of participants have been described in a separate study previously published ( To further assess the effect of NAC treatment in modulating host immune response, we measured the concentration of several cytokines, chemokines, growth factors and lipid mediators in plasma isolated from patients receiving or not NAC at the study baseline and day 60 of treatment (see Methods for details in the choice of the parameters)

The gene product (CFTR) is a large (1480 amino acids, 175000 Daltons), ligand gated ion channel belonging to the ABC transporter family