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13,14,15 Additionally, impaired neurotrophic support and autoimmune mechanisms may further exacerbate neuronal degeneration

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Additionally, there was an increase in the cleavage of apoptotic markers such as caspase-3, caspase-8, and caspase-9 (254)

The fact that H 2 O 2 production is enhanced under stress conditions, it will be interesting to evaluate how the activities of AO and APX enzyme are comparatively regulated and to what extent they contribute to stress perception and downstream signaling events