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Their pathological mechanisms are complex and interrelated, with the core issue lying in the progressive dysfunction of mitochondrial function in neuronal cells-where overloaded oxidative stress, depleted energy metabolism, and uncontrolled apoptosis form a vicious cycle

Wiencke et al, 2007)

What are the recommended dosing regimens, safety monitoring, and clinical trial considerations for senolytic agents such as dasatinib + quercetin, navitoclax, fisetin, and FOXO4DRI?