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(1996) observed decreased expression of DA, TH, and DAT in the striatum of chronic METH abusers post mortem , which might explain the dysphoric effects of the drug and dose escalation observed in some METH users (Wilson et al., 1996)

To overcome these problems, various halogenated derivatives (e.g., chlorinated or boronated PBN), alkylated derivatives having a lipophilic tail (e.g., those with dodecyl chains), bifunctional derivatives (e.g., GS-PBN, Mito-DEPMPO, 5-ChEPMPO, DECPO, and 4-HMDEPMPO), conjugates with drugs or targeting molecules (such as PEG or heparin, that both can cross the BBB), dimers, and cyclodextrin polymers have been developed in the last few years (Han et al., 2009

My lab is not only looking at the skin, but we are also looking at the brain, says Sommer

doi:10.1080/02763869.2019.1588072 18