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Kupffer Cells: Liver-resident macrophages that play an essential role in iron recycling

Similarly, no significant changes in LINE-1 and Alu methylation among female nurses was observed, although several gene-specific hypomethylation effects to the estrogen receptor gene ESR1 (associated with heightened estrogen sensitivity), to the tumor suppressor genes TP53 and BRCA1 (indicating possible disruption in cell cycle regulation and DNA repair mechanisms) were reported