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The structural basis for orforglipron's mechanism was published in the Proceedings of the National Academy of Sciences in 2020, revealing through cryo-electron microscopy (cryo-EM) how a small molecule could stabilize the active conformation of a class B GPCR, a finding that fundamentally changed the field's understanding of GPCR pharmacology

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Clin Pharmacokinet 19(3):241255 Gilmore DA, Gal J, Gerber JG, Nies AS (1992) Age and gender influence the stereoselective pharmacokinetics of propranolol