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Icariin (ICA) activates the SLC7A11/GPX4 signaling pathway, mitigating chondrocyte ferroptosis and protecting cartilage (Xiao et al., 2024)

The oxidant-modified cysteine C173 in PMK-1 shows a high degree of conservation from worms to humans and is located adjacent to the magnesium-binding DFG motif within the kinase activation loop (Fig