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Chemistry panel : Hyperglobulinemia: If electrophoresis was performed, one may see a polyclonal gammopathy (from an acquired immune response) and an increase in 1 (cats) or 2 (other species)-globulins if there is acute or ongoing inflammation (positive acute phase response)

For example, a DNA repair protein, redox factor Ref-1, was reported to promote the DNA-binding activities of several transcription factors, including HIF-1 and p53, which confers cytoprotective function under hypoxia

10.1212/01.WNL.0000152046.11390.45 Neurology