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Moreover, chondrocyte apoptosis, triggered by ER stress, nitric oxide, and oxidative insults, plays a critical role in cartilage degradation

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Methods This small case study is comprised of two test subjects, a 34 year-old male and a 47 year-old male, both of which have been on testosterone replacement therapy for greater than a five year duration, and both of which were verified and documented to have suppressed endogenous luteinizing hormone levels (0.1) prior to commencement of the study

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