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The occurrence and development of different diseases are associated with abnormal GSH metabolism through different mechanisms: Glutathione dynamics during sepsis Sepsis is characterized by severe redox imbalance, and glutathione plays a key role in combating oxidative and nitrosative stress

Physiologically, and similar to apoptosis of nucleated cells, eryptosis occurs to ultimately eliminate damaged senescent, and damaged or dysfunctional mature erythrocytes from the circulation [204]

N The protein expression of HSP90 and GPX4 was examined by WB in LLC cells-derived subcutaneous xenografts tumor

As proof of principle, we have developed small molecules that target PTPs, termed redox-based probes (RBPs, Fig