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These ubiquitous chemicals in the environment and food supply have substantially contributed to the marked rise in autoimmune disorders over the last 2-3 decades

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Patients who judge their progress entirely by the scan numbers at week 12 often conclude the treatment is not working

In a further aspect of the invention, one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that increase intracellular NAD+ levels to provide muscular therapy is contacted with a cell expressing NNMT followed by contacting said cell expressing NNMT one or more NNMT inhibitors (such as a cation of Formula I or IA, or otherwise disclosed herein)