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This behavior could be explained by two competing processes, photodegradation, which contributes more to the first step, and absorption, which is predominant in the second step

Regarding the toxicity of pemetrexed, low-risk factors for hematological AEs were high WBC count before pemetrexed exposure, the standard dosage of chemotherapeutic agents, MTHFR_a polymorphisms, high B12 level before premedication, and a high FA level before pemetrexed exposure (Fig