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PDRN (polydeoxyribonucleotide) activates dermal adenosine A2A receptors to drive fibroblast activity, angiogenesis, and anti-melanogenesis

This approach mirrors strategies used with other peptide therapies to optimize tolerability

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It induces apoptosis in malignant cells by upregulating p27kip1 and Caspase-3, acting as a "smart" molecule that supports healthy cells while targeting damaged ones