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Also, valproate (VPA) may increase risk of lamotrigine-induced Stevens Johnson Syndrome (SJS) by a different mechanism

Glutathione competitively inhibits melanin synthesis by interrupting L-DOPAs ability to bind with tyrosinase during melanin synthesis

However, as reviewed by Lucas et al

Acknowledgements Maria Tellez-Plaza was supported by the Strategic Action for Research in Health sciences (CP12/03080), which is an initiative from Carlos III Health Institute Madrid and the Spanish Ministry of Economy and Competitiveness and co-funded with European Funds for Regional Development (FEDER)