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PARPs, on the other hand, respond to DNA damage by using NAD + to generate ADP-ribose polymers, which are essential for DNA repair and maintaining genome stability

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321,336 Altered phosphorylation of insulin receptor substrate proteins, particularly IRS-1 and IRS-2, is implicated in neuronal insulin resistance, 20,337 which impairs insulins neurotrophic effects, leading to reduced neurite outgrowth and increased vulnerability to injury