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Courrol and de Matos, 2016)

Geroprotective effect of epithalamine (pineal gland peptide preparation) in elderly subjects during accelerated aging

308 In experimental autoimmune uveitis (EAU) mice, CD4 + T cells display high lactate levels, leading to hyperlactylation of Ikzf1 at K164, which further modulates the expression of Th17-related genes, including Runx1, Tlr4, IL-2, and IL-4, consequently promoting Th17 differentiation