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However, mTORC1 activation only promoted metabolic reprogramming of Gclc -deficient FoB but was not sufficient to ensure antibody production, in contrast to B cell cells isolated from tuberous sclerosis complex 1 (TSC1)-deficient mice 102

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Even at higher CSE concentrations (e.g., 5%), the secretion of IL-8, MCP-1, and growth-regulated oncogene- (GRO-) diminishes (61)

First, the vast majority of available data derives from animal studies, and extrapolation to human applications may not be straightforward due to species differences in physiology and drug metabolism