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Accumulating evidence indicates that lipid metabolism reprogramming and specific signaling molecules play crucial roles in the activation and persistence of MF and the production of ECM

This aligns with broader biohacking trends focused on maintaining youthful function as we age

The main cellular sources of ROS are mitochondrial metabolism and NADPH oxidase (NOX) at the cell membrane (Fig

doi: 10.3389/fmicb.2026.1751932 Received 22 November 2025 Revised 20 January 2026 Accepted 22 January 2026 Published 23 February 2026 Volume 17 - 2026 Edited by Bijay Kumar Behera, Central Inland Fisheries Research Institute (ICAR), India Reviewed by Manivannan Paramasivan, Bharathidasan University, India Walter Jose Martinez Burgos, National Institute of Amazonian Research (INPA), Brazil Updates Copyright 2026 Srivastava, Mir, Hussain, Mitra, Srivastava, Kumar and Kaur