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Therefore, large-scale, multi-center randomized controlled trials are needed to evaluate the efficacy and safety of specific antioxidants in diverse patient populations

As the pathologic progress continues, the neurodegeneration of formerly impaired regions is also aggravated (Braak et al., 2020)

Vasilakou et al., 2016)..Because the biological experiments provide the flux information needed to construct the models, accurate identification of metabolites and determination of flux changes is critical to the accuracy of subsequent predictions of network properties made using the models (Acosta et al., 2007)

Modulation of glial cell functions by the gut-brain Axis: a role in neurodegenerative disorders and pain transmission