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10.1073/pnas.95.19.11140 60 HanW.LiH.ChenB

eLife 12, RP92362

Mechanistically, butyrate inhibits mTORC1, attenuates eIF2ATF4-dependent ISR signaling, and represses DGAT/ACSL-dependent LD biogenesis, whereas microglial Rptor overexpression abolishes these protective effects, identifying mTORC1 as an upstream metabolic checkpoint