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Traditional methods such as liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-mass spectrometry (GC-MS), which integrate chromatography and mass spectrometry, are currently the mainstream techniques for detecting metabolites in tumors, but they face limitations in terms of low detection efficiency for metabolites with strong polarity, isomerism, and low ionization efficiency

P.et al (2020)

Activated immunocytes release cytokines such as IL-6 and TNF-, thus promoting the migration of antigen-presenting cells (APCs)

The regulation of FPN1 was attributed to an intra-tumoral response to hypoxia which led to an up-regulation of locally produced hepcidin [81]