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Dietary allicin reduces transformation of L carnitine to TMAO through impact on gut microbiota ScienceDirect Heart failure and trimethylamine Noxide: time to transform a 'gut feeling' in a fact? Crisci 2023 ESC Heart Failure Wiley Online Library Frontiers Association between fatigue, peripheral serotonin, and L carnitine in hypothyroidism and in chronic fatigue syndrome The Basics of Metabolic DysfunctionAssociated Steatotic Liver Disease for Cardiologists: Pathophysiology, Diagnosis, and Treatment JACC

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Mikuls TR, Duryee MJ, England BR, Anderson DR, Hearth-Holmes M, Su K, et al

In addition to AGEs and AGE adducts, HMGB1 and A can bind RAGEs to activate the NF-B, ERK1/2, p38, JNK, PI3K, Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathways, leading to neuronal cell death and neurodegeneration 112