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In the human knee joint, the selenium concentration in cartilage is approximately 80 g/kg dry weight, whereas the selenium concentrations in ligament and meniscus are 270 and 307 g/kg dry weight, respectively 60,61

Pediatric pharmacokinetics and long-term safety require clarification, particularly for polyphenols and carotenoids with intrinsically low oral bioavailability and potential interactions with conventional medications like antipsychotics or stimulants (Hendouei et al., 2020

In addition, the supplementation of selenium, alone or together with vitamin E, did not show any benefits regarding the risk of prostate, lung, or colorectal cancers after 5.5 years of follow-up (86, 87)

Measurement of LDH activity Lactate Dehydrogenase (LDH) activity was measured by a standard kit (A020-2, Nanjing Jiancheng Bioengineering, China)