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doi: 10.1023/A:1007015027268

Brain MRI imaging is normal in SPS and SPS-SD, but magnetic resonance spectroscopy studies have shown prominent and significant reduction in GABA predominantly in the sensorimotor cortex and to a lesser degree in the posterior occipital cortex, indicating involvement of the inhibitory GABAergic pathways [22]

Clinical Status Human RCT | Observational | Animal | In vitro Primarily studied in preclinical anabolic and metabolic research contexts, with limited exploratory human data

pruriens roots, stems, leaves, and bean, low convergences of estimated alkaloids are roughly reported to be 0.001%