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Based on this, immunomodulators regulate the density and distribution of tumor antigens so they can overcome the heterogeneity and loss of antigens that pave the way for CAR-T cell function

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Stanley CA, Fang J, Kutyna K, et al

In a further aspect of the invention, one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that modulate intracellular NAD+ levels to provide muscular therapy is contacted with a cell expressing NNMT followed by contacting said cell expressing NNMT one or more NNMT inhibitors (such as a cation of Formula I or IA, or otherwise disclosed herein)