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By blocking the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) pathways, curcumin prevents the generation of highly inflammatory lipid mediators like leukotrienes (LTC4) and prostaglandins (PGD2)

It leads to upregulation of proteins involved in different biological processes such as metabolism, inflammation, and apoptosis

Furthermore, a randomized clinical trial demonstrated that combining daptomycin with fosfomycin for MRSA bacteremia resulted in a 12% higher success rate compared to daptomycin alone, and led to a 17.8% reduction in mortality in vancomycin-resistant Enterococcus bloodstream infections (Pujol et al., 2021)

As analgesic (300 to 600mg during 6 to 8h) for head-ache, backache, pulled muscle, toothache, neuralgias as antipyretic in fever of any origin in the same doses as for analglesia