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Moreover, SYP-14288-resistant mutant X19-7 significantly enhanced SYP-14288 metabolism on M1, and M1 accumulation in X19-7 might account for the decrease of the sensitivity to SYP-14288, whereas M2 and M3 were less important in the resistance

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1 Like trojanrapamycin April 28, 2026, 4:06pm #4 I will add low membrane permeability was achieved by fusing an HIV-TAT peptide (or HIV-TAT sequence) to facilitate membrane transport and enhance cellular uptake