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Most people find this to be uncomfortable, but not unbearable, and it dramatically impacts the results you get - so its a tradeoff most people are willing to make

People on certain medications: Some medications can interfere with the absorption or metabolism of vitamin B12, including proton pump inhibitors (PPI), metformin, nitrous oxide anesthesia, some epileptic medications, and colchicine (for gout)

Its regenerative properties for muscles, tendons, ligaments, and other soft tissues are promising

Microdosing: which concentration works best Microdosing tirzepatide at 1mg to 1.25mg per week is growing in popularity for specific protocols