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J Biol Chem 287 , 44034410, doi: 10.1074/jbc.R111.283432 (2011)

A common DIO2 haplotype composed of the minor C-allele of SNP rs225014 and the common C-allele of SNP rs12885300 was significantly associated with advanced hip OA, as indicated by a higher odds ratio 101,102,103

Both glycolytic substrate level phosphorylation as well as mitochondrial oxidative phosphoylation contribute to ATP regeneration from ADP and both processes have reserve capacity to compensate at least in part for an impairment of the other process

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