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doi: 10.3390/ph3010125

[10] [9] A skeptical reading is available and should be stated: an intervention whose reported benefits appear late, persist for a day, and continue after discontinuation is an intervention whose reported benefits are difficult to distinguish from expectation, regression to the mean, and the substantial placebo response that characterizes insomnia research generally

You'll need to remove the needle and try again in a different spot

However, if left untreated, a severe deficiency can cause serious complications such as neurological disorders, vision problems, depression, and, in some cases, may be linked to certain types of cancers