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Samples should therefore be stored for a short period at 2 - 8 C or aliquoted at -20 C (1 month) or -80 C ( 3 months)

Sodium hydroxide and/or hydrochloric acid is added to adjust pH (range 6.0 - 7.5)

The accelerated approval of tofersen for SOD1-ALS marks a pivotal advance in precision medicine but also highlights a critical gap: effective strategies for the vast majority of patients without such targetable mutations (8, 9)