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they therefore need an adequate supply of nutrients

Although the specific reason for the difference in findings remains to be determined, these studies highlight the importance of considering the limitations of the MRS sequence, alongside the size and composition of the participant cohort, to present a valid interpretation of the results

These findings support the safety and potential disease-modifying effects of FUS-mediated BBB opening in early-stage AD, although larger trials are warranted to establish clinical efficacy (Rezai et al., 2024)

Such a response is reminiscent of that of the daf-2 mutant, where daf-16 and xbp-1 act to maintain ER homeostasis (and increasing the lifespan) without inducing HSPs 66