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In a study by Vanderhoof et al., 41 oral erythromycin (20 mg/kg/day) was tried to patients with CVS as a prokinetic agent, which was suggested to be effective in some patients, but the efficacy was not confirmed due to poor quality of the study

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These extremely low GA infants may not have surfactant deficiency or RDS but instead have early requirements for oxygen and ventilatory support due to multiple factors leading to respiratory instability of prematurity 127,128,129