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In the CY 2025 PFS proposed rule, we proposed to maintain the data completeness criteria threshold of at least 75 percent for 2 additional years

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Variability in mucociliary clearance speed and mucus thickness, often affected by patient conditions such as anatomical differences, inflammation or allergies, and even the technique of administration (angle of spray, depth of insertion) (Riese et al., 2014), can alter drug absorption and uptake into the brain