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Description

Selective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGF beta signalling and EMT

Cachexia is a marker for poor cancer prognosis, occurring in about 80% of patients and accounting for at least 20% of cancer-related deaths (164166)

Dysfunction of mitochondria can lead to impaired insulin sensitivity

Mice experiments were performed in accordance with the guidelines of the Declaration of Helsinki and the local research ethics committee, as described in protocol number MD-21-16451-5