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Some therapies increase the risks of infections, and some may increase the risk of other autoimmune conditions

ICI therapies disrupt the sensing of inhibitory receptor signals delivered from the transformed tissue by tumor-specific T or NK cells to reinvigorate their cytotoxic capacity ( In spite of the apparent effectiveness of ICI-based immunotherapies, they often work only in a subset of patients ( 2 Materials and methods 2.1 Ethics approval and consent to participate Fresh blood samples were obtained from healthy volunteers and patients in accordance to the Helsinki declaration

The 5272 hairs in this study significantly exceeds those numbers, though direct comparison requires caution because patient populations, measurement methods, and baseline conditions differ