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These shifts can disrupt nutrient absorption and metabolism, interfere with insulin signaling, and enhance inflammatory responses, thus heightening T2DM risk ( Overview of AMPK signaling pathways Adenylate-activated protein kinase (AMPK), also known as AMP-dependent protein kinase, is a pivotal element in diabetes research and other metabolism-related disorders

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Polynucleotide and Polypeptide Variants The present invention also encompasses variants (e.g., allelic variants, orthologs, etc.) of the polynucleotide sequence disclosed herein in SEQ ID NO:1, the complementary strand thereto, and/or the cDNA sequence contained in the deposited clone

(5) Dysbiosis and the release of inflammatory markers (LPS) (Ridlon et al., 2015) further lead to BT, endotoxemia, and intestinal barrier damage, significantly correlating with liver cirrhosis progression and cognitive impairment (Zhang et al., 2022)