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In contrast, E-cadherin mRNA expression was highly attenuated in Igf1r fl/fl mice upon experimental pulmonary metastasis, while this reduction was milder in CreERT2 mice (Fig

All chemicals and solvents used were of the highest commercially available grade

The most common initial symptom in this large series, observed in 68% of the patients when first seen, was the insidious onset of proximal leg stiffness followed by rigidity concurrently in the abdominal, lumbosacral and thoracic paraspinal muscles, lumbar hyperlordosis and impaired gait

Nevertheless, their dose-dependent toxicity, particularly thrombocytopenia and neutropenia, represents a significant barrier to their widespread use [193]