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Molecules (2019) 24(8):1582

In cancer cells, 2HG is a competitive inhibitor of 2OG-dependent dioxygenases, including TET and JMJ family demethylases

6.1.4 Clinical evidence Recent meta-analyses have demonstrated that probiotic, prebiotic, or synbiotic interventions significantly improve symptoms of depression, anxiety, and stress ( Bifidobacterium and Lactobacillus strains demonstrating the most consistent beneficial effects ( liwka et al., 2025