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Several herbal components were reported to have the same therapeutic effect as NAC (Mukazayire et al., 2010

doi: 10.1007/s11064-022-03598-w

demonstrated that lactate promotes PFKFB3-driven angiogenesis through AKT phosphorylation [22], while lactate also induces EC permeability via extracellular signal-regulated kinase (ERK)-dependent activation of calpain1/2 to disrupt vascular endothelial (VE)-cadherin [53]