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A 52-week phase 2 trial on AMG133 in people with overweight and obesity is ongoing (NCT05669599)

Zepbound (tirzepatide) is approved for weight loss, while Ozempic (semaglutide) is approved for type 2 diabetes, though in some cases it may be prescribed off-label for weight loss

The increase in TNF stimulates osteoclastogenesis and/or enhances osteoblast apoptosis, thus disrupting normal bone homeostasis leading to bone loss [138, 139]