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Vargas MR, Johnson DA, Sirkis DW, Messing A, Johnson JA

These studies have elucidated that the focal inflammatory demyelinating lesions in the WM that underlie the acute attacks in early MS contain CD4 + and CD8 + T cells, activated macrophages and microglia, and show evidence of active demyelination and axonal transection and injury ( With aging of MS, peripheral immune-mediated inflammation subsides and WM lesions evolve either into inactive plaques that only have sparse immune cells present or alternatively smoldering lesions that have a demyelinated core with a rim of activated microglia along the lesion edge in close proximity to lymphocytic perivascular cuffs (alternatively referred to as chronic-active or mixed active/inactive lesions)

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10.1038/s41467-020-15508-1 12