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Description

Pseudomonas aeruginosa exemplifies an organism that has evolved unusually robust, multi-layered defensesdeploying periplasmic surveillance and export (CopRSPcoBA), cytoplasmic sensing and efflux (CueR-regulated CopA/CzcR regulated CzcCBA system), and an additional small-molecule strategy in which copper is neutralized by sequestration into the organometallic complex fluopsin C

Simulated comparison of a Bayesian clinical decision support system versus standard of care for achieving gentamicin pharmacokinetic targets in neonates