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doi: 10.3390/nu17030428 9 QinHKingGJBorpatragohainPZouJ

Serum LBP Is Associated with Insulin Resistance in Women with PCOS

Disease states that affect intra-portal insulin levels by increasing insulin resistance causing compensatory intra-portal hyperinsulinemia or by decreasing pancreatic -cell insulin secretion causing intra-portal hypoinsulinemia results in changes to hepatic IGF-I synthesis and secretion, and consequently changes in GH levels via the negative feedback loop