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Administration of intravenous thiamin to WKS patients generally results in prompt improvement of the eye symptoms, but improvements in motor coordination and memory may be less, depending on how long the symptoms have been present

(2011) 6:e18237

These changes increase the risk of infertility, subfertility, and chromosomal aberrancies in sperm

Clinical implications Current evidence supports the following practice recommendations: implement MT-RNR1 screening in NICU settings where rapid testing infrastructure is available (Table 5) and vestibular monitoring (Table 6, particularly following gentamicin exposure) ( Despite optimal management, some children will sustain permanent hearing loss