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In addition, HA-ADT-induced apoptosis was evidenced by the downregulation of the expressions of p-glycogen synthase kinase-3 (GSK-3), phospho (p)-protein kinase B (PKB/AKT) and p--catenin, and suppressed autophagy through decreasing the expressions of transforming growth factor- (TGF-) and p-Smad2/p-Smad3 in human HCC cells

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