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Background: Wilson Disease (WD) is a rare disorder caused by mutations in the ATP7B gene (encodes transporter protein to regulate copper levels) that cause a toxic buildup of copper in the liver, brain, and other organs and can result in liver disease, neurological symptoms, and psychiatric behavioral disorders

This paradoxical result, where mice eat more but weigh less on a low methionine diet, was also seen in an independent study of male mice of a genetically heterogeneous background ( Not all mouse studies of low methionine resulted in longer life though

Comparison of mTOR inhibitors combined with endocrine therapy versus that alone in breast cancer: a meta-analysis

Prognosis [edit] An elevation in serum bilirubin level of more than 2 times ULN with associated transaminase rise indicates severe hepatotoxicity and is likely to lead to mortality in 10% to 15% of patients, especially if the offending drug is not stopped (Hy's Law)