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Mannino G, Pernici C, Serio G et al (2021) Melatonin and phytomelatonin: chemistry, biosynthesis, metabolism, distribution and bioactivity in plants and animals-an overview

Methods: Patients with cirrhosis were screened on transthoracic echocardiography (TTE) with tissue Doppler imaging for presence of LVDD, and those with ischemic heart disease, pacemaker in situ or known arrhythmia, prior use of beta blocker, valvular heart disease, anemia, uncorrected thyroid dysfunction, and hepatocellular carcinoma were excluded

In post-injury models (e.g., reversing established dopaminergic axonal degeneration or promoting striatal neuron regeneration), BDNF has no proven neurorestorative effectsa key limitation compared to GFLs [62]