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coli , leads to a shift in microbial composition that disrupts normal metabolic processes [82, 83]

Stress can negatively impact fertility, but worrying about fertility is stressful, so it can be a bit of a catch-22

KG, 3 Department of Medical Sciences, Division of Gastroenterology, University of Turin, 4 The Texas Liver Institute, University of Texas Health San Antonio, and Arizona Liver Health, 5 Boehringer Ingelheim International GmbH, 6 Department of Internal Medicine II, Saarland University Medical Center, 7 National Institute for Health Research Biomedical Research Centre, University Hospital Birmingham, 8 Faculty of Medical Sciences, Newcastle University, 9 Covenant Metabolic Specialists, LLC, 10 Texas Liver Institute, University of Texas Health San Antonio, 11 The Institute of Cardiometabolism and Nutrition, Sorbonne Universit, Hpital PitiSalptrire, 12 Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, 13 Boehringer Ingelheim Pharmaceuticals, Inc., 14 Virginia Commonwealth University Background: We evaluated non-invasive liver biomarkers from a phase II trial of survodutide, a novel glucagon receptor/glucagon-like peptide-1 receptor dual agonist for the treatment of metabolic dysfunction-associated steatohepatitis (MASH) and fibrosis

This imbalance of the gut microbiota and continued exposure of the colonic epithelial cells to urea is harmful to intestinal epithelial barrier function as it aids the disruption of the mucus layer and lowers the expression of tight junction proteins (Vaziri et al., 2013