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Shokolenko et al., 2014

Prostanoids are rapidly metabolized, producing numerous metabolites, including the prostaglandin PGI 2 , which is formed by the action of PGI synthase on PGH 2 and rapidly hydrolyzes to a stable but biologically inactive metabolite, 6-ketoprostaglandin F1 (6-keto PGF 1 ) [109]